Plasma requires 20-30 minutes to thaw.
Plasma is issued according to the patient’s blood type.
Do not transfuse plasma for its colloidal properties or volume expansion.
a. with aPTT greater than 1.5 times the mean aPTT (45 seconds)
b. INR greater than 1.8 times the mean PT
|Factor Deficiency||Level Required for Surgical Hemostasis||Factor
|Fibrinogen||100 mg/dL||72-120 hours|
|Factor V||10-30%||12-36 hours|
|Factor VII||10-25%||4-7 hours|
|Factor X||10-40%||24-48 hours|
|Factor XI||15-50%||40-84 hours|
|Factor XII||0%||48-52 hours|
|Factor XIII||5-50%||9-12 days|
|Reference: Van Cott, Laposata. Coagulation, Fibrinolysis, Hypercoagulation. Clin Diag management by Lab Methods 20th ed, Henry, JB, ed. NY: W B Saunders, 2001: 642-59.|
Cryoprecipitate ComponentsCryoprecipitated Antihemophilic Factor (AHF) (cryoprecipitate) contains fibrinogen, Factor VIII, von Willebrand Factor and Factor XIII.
|150-250 mg of fibrinogen
40-70% von Willebrand Factor
80-120 units Factor VIII and
20-30% Factor XIII
|Volume:||Approximately 5-20 mL per unit|
|Storage:||A unit of thawed cryo must be maintained at room temperature and fully transfused within 4 hours of release from the Blood Bank|
|Dose:||Adult and child: One unit of cryo per 10 kg body weight. Adult units are pre-packaged pools of five.|
|Expected Result:||Adult: Each unit will increase fibrinogen by approximately 7 to 10 mg/dL.
Child: Each unit will increase fibrinogen by approximately 6 to 10 mg/dL.
1. Hypofibrinogenemia. Fibrinogen levels greater than 100 mg/dL are generally considered adequate for hemostasis. When the fibrinogen level is between 100 to 150 mg/dL, cryo should be considered for the following:
a. Active bleeding
b. Consumptive coagulopathy
c. Prolonged cardiopulmonary bypass or ECMO, when temporary fibrinogen dysfunction is suspected
d. Newborns at significant risk for intracranial hemorrhage
e. Factor XIII deficiency
f. Patients with von Willebrand’s disease who are:
2. Fibrin surgical adhesive: A single unit of cryo is available for surgical use. However, commercial fibrin sealants available from the pharmacy are preferred because they have been treated with a viral inactivation step.