A subset of white blood cells that includes neutrophils, eosinophils and basophils. These are collected and transfused under special circumstances after consultation with a transfusion medicine physician.
Presence of blood or red blood cells in the urine.
The presence of free hemoglobin in the blood plasma.
Presence of free hemoglobin in the urine.
Human leukocyte antigens are a group of protein molecules located on the surface of nucleated cells and platelets. HLA helps the immune response to distinguish between self and non-self. Antibodies against HLA molecules can lead to incompatible organ transplants and platelet transfusions.
Abnormal deficiency in the concentration of oxygen in arterial blood. PaO2 / FiO2 less than or equal to 300 mm Hg or oxygen saturation is less than 90% on room air.
Gamma or electron treatment of a cellular blood product to disable proliferation of nucleated cells. This protects against transfusion-associated graft versus host disease.
New onset or worsening of yellow discoloration (icterus) of the skin or sclera (scleral icterus) secondary to an increased level of bilirubin.
The component is filtered at the time of collection to remove most, but not all, white blood cells.
New onset of decreased urinary output (less than 500 cc output per 24 hours).
Non-urticarial skin rash.
The liquid portion of whole blood, containing water, electrolytes, glucose, fats, proteins, and gases. Plasma contains all the clotting factors necessary for coagulation in an inactive form. Once coagulation occurs, the fluid is converted to serum. Plasma also contains antibodies that can lead to incompatible red blood cell transfusions.
Rh is a group of antigens expressed on the surface of the red blood cell. The D antigen, commonly referred to as Rh or Rh(D) antigen, is the most immunogenic. Approximately 15% of blood donors lack the D antigen and are commonly referred to as Rh or D negative.
A drop in blood pressure accompanied by a drop in cardiac output including rapid heart rate (increase to 100 beats per minute or more), rapid breathing, cutaneous vasoconstriction, pallor, sweating, decreased or scanty urine production, agitation and/or loss of consciousness that required fluid resuscitation, with or without inotropic support.
Shortness of Breath (dyspnea):
New onset or significant worsening of shortness of breath or a significant increase in respiratory rate (with or without hypoxemia).
Transfusion-Related Acute Lung Injury is an acute syndrome including dyspnea, hypoxemia, and interstitial pulmonary infiltrates presenting within six hours of transfusion in the absence of other detectable causes.
TACO: Transfusion-Associated Circulatory Overload is a possible consequence of transfusion in patients with cardiac insufficiency, renal impairment, or already expanded blood volumes.
Urticaria (hives): Raised red spots (with or without itching).