A peptic ulcer is a sore in the lining of your stomach or in the first part of your small intestine (duodenum). It can cause belly (abdominal) pain and other symptoms. In some cases, a peptic ulcer may get worse. This can lead to serious problems such as bleeding or a hole (perforation) in the stomach or duodenum. Treatment is needed to prevent these complications. With treatment, most people fully recover.
A peptic ulcer can be caused by:
Infection from H. pylori (Helicobacter pylori) bacteria
Long-term use of pain medicines called non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen
Physical stress such as burns, head injuries, needing a breathing tube, or being on blood- thinning medicine
Other rare causes
The lining of your stomach and duodenum is coated with a thick mucus layer. This helps protect the stomach and duodenum from the acids and enzymes they make to help break down the food you eat. When H. pylori is present, it can weaken the mucus layer and irritate the lining underneath. Acid may pass through the weakened mucus layer and cause an ulcer to form. Overuse of NSAIDs can also damage the mucus layer, leading to ulcers.
Peptic ulcers may or may not cause symptoms. If you do have symptoms, they may come and go. They may also range from mild to severe. Common symptoms include:
Burning, cramping, or hunger-like pain in the stomach area (often 1 to 3 hours after a meal, or in the middle of the night)
Pain that gets better or worse with eating
Loss of appetite
Nausea or vomiting (vomit may be bloody or look like coffee grounds)
Black, tarry, or bloody stools (this means the ulcer is bleeding)
Your healthcare provider will ask about your symptoms and health history. You’ll also have a physical exam. In addition, tests will be done to confirm the problem. These tests also help determine if an ulcer is caused by H. pylori. Tests can include:
Blood, stool, or breath tests. These are done to check for H. pylori and other problems. For blood and stool tests, small samples of your blood and stool are taken. The samples are sent to a lab for exam. For a breath test, you'll drink a liquid that contains a harmless compound. H pylori causes the compound to break down and release carbon dioxide gas. By testing the air you breathe out after you drink the liquid, the doctor can tell if the bacteria are present.
Upper endoscopy. This test is done to see inside the stomach and duodenum. This lets your provider check for ulcers. During the test, an endoscope (scope) is used. This is a thin, flexible tube with a tiny camera on the end. The scope is inserted through your mouth. It is then guided down into your stomach or duodenum. If needed, tiny tools may be passed through the scope to take tissue samples (biopsy). Treatment can also be done at the same time if bleeding or other problems are found.
Upper gastrointestinal (GI) series. This test is done to take X-rays of your upper digestive tract from your mouth to the small intestine. This lets your provider check for ulcers. For this test, you’ll drink a milky liquid that has a substance called barium. The barium coats your upper digestive tract so that it will show up clearly on X-rays.
Medicines are the most common treatment for peptic ulcers. They include:
Antibiotics. These kill H. pylori bacteria. In many cases, you’ll need to take at least 2 types of antibiotics.
Proton pump inhibitors. These block your stomach from making any acid.
H2 blockers. These reduce the amount of acid your stomach makes.
Bismuth subsalicylate. This helps protect the lining of your stomach and duodenum from acid.
Be sure to take all of the medicines that you’re prescribed exactly as instructed. Don’t stop taking the medicines, even if you are feeling better. The medicines may cause side effects. Your healthcare provider will tell you more about these based on which medicines you are prescribed. During treatment, avoid taking aspirin and other NSAIDs. You may also be told to avoid cigarettes, alcohol, and caffeine. These may worsen your symptoms or affect how well your ulcer heals. If your stress level is high, reducing stress may help.
In severe cases, other treatments will likely be done. These may include procedures with an endoscope or surgery. Your provider will tell you more about these treatments, if needed.
Call your provider right away if you have any of the following:
Fever of 100.4°F (38°C) or higher, or as advised by your provider
Frequent vomiting, blood in your vomit, or coffee ground-like substance in your vomit
Sudden or severe abdominal pain
Dark, tarry, or bloody stools
Pain that doesn't get better, even with treatment
Take the following steps to help prevent a peptic ulcer:
Reduce your risk of H. pylori infection. Most experts think that H. pylori can be passed through food or water that is contaminated by an infected person. For your safety, the CDC recommends following basic hygiene. For instance, always wash your hands with warm water and soap after using the bathroom. Also wash your hands before preparing and handling food. And only drink water from safe sources.
Limit the use of aspirin and NSAIDs. Work with your provider to change your medicine or to reduce the amount of NSAIDs you take. If you must take aspirin or NSAIDs, ask your provider about other pain medicines you can take to help protect your stomach and duodenum. Sometimes other pain medicines can be used instead. But if you take aspirin because of a heart condition, blood clot, or stroke, talk with your healthcare provider first before you stop taking aspirin.
Quit smoking. Quit other forms of tobacco too.