Maraviroc, Oral

What are other names for this medicine?

Type of medicine: CCR5 antagonist; antiretroviral (anti-HIV)

Generic and brand names: maraviroc, oral; Selzentry

What is this medicine used for?

This medicine is taken by mouth to treat HIV-1 infection. It is not known whether this medicine is effective against HIV-2 infection. This medicine is usually taken with other medicines.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• an allergic reaction to any medicine
• diabetes
• heart disease or heart rhythm problems
• hemophilia or bleeding problems
• high cholesterol or high triglycerides
• kidney problems
• liver disease.

Females of childbearing age: Tell your healthcare provider if you are pregnant or breast-feeding. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Take this medicine exactly as your healthcare provider prescribes. Do not change your dosage on your own. Do not stop taking this medicine without your healthcare provider's approval. If you are not sure of how much and how often to take this medicine, ask your healthcare provider or pharmacist to explain.

Take this medicine with other medicines your healthcare provider prescribes. Follow your healthcare provider's instructions exactly.

You may take this medicine with or without food.

Do not miss any doses. If you do miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What should I watch out for?

This medicine is not a cure for HIV infection. You may continue to get illnesses associated with advanced HIV infection, including other infections. There is no evidence that this medicine will reduce the risk of spreading HIV through sexual contact or blood contamination.

You will need to have blood tests regularly to see how this medicine affects you. Keep all appointments for these tests.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

Do not give this medicine to other people, even if they have the same symptoms you have.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider about any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Severe diarrhea; stomach pain; yellowing of the eyes or skin; rash; nausea; dizziness; lightheadedness; increased thirst and urination; numbness or tingling of the hands or feet; fast, slow, or irregular heartbeat.

Other: Headache, fever, cough, fatigue, depression, trouble sleeping, gas, vomiting, muscle pain.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• alcohol
• antacids (take them 1 hour before or after doses of this medicine)
• antiarrhythmics such as amiodarone (Cordarone), flecainide (Tambocor), propafenone (Rythmol), mexiletine, dofetilide (Tikosyn), disopyramide (Norpace), quinidine (quinidine gluconate, quinidine sulfate), and lidocaine
• antibiotics such as azithromycin (Zithromax), clarithromycin (Biaxin), and erythromycin (EryC, Ery-Tab, E.E.S., Erythrocin)
• antidepressants such as bupropion (Wellbutrin, Wellbutrin SR, Zyban), fluoxetine (Prozac, Sarafem), sertraline (Zoloft), paroxetine (Paxil), trazodone (Desyrel) and nefazodone
• antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), posaconazole (Noxafil), voriconazole (VFEND), and ketoconazole (Nizoral)
• antipsychotic medicines such as clozapine (Clozaril), pimozide (Orap), perphenazine (Trilafon), risperidone (Risperdal), aripiprazole (Abilify), olanzapine (Zyprexa), and thioridazine
• antiseizure medicines such as carbamazepine (Tegretol), oxcarbazepine (Trileptal), fosphenytoin (Cerebyx), phenobarbital, clonazepam (Klonopin), ethosuximide (Zarontin), divalproex sodium (Depakote, Depakote ER), lamotrigine (Lamictal), and phenytoin (Dilantin)
• atovaquone (Mepron)
• blood thinners such as warfarin (Coumadin), clopidogrel (Plavix), ticlopidine (Ticlid), heparin, and aspirin
• buspirone (BuSpar)
• cabergoline (Dostinex)
• corticosteroids such as dexamethasone (Decadron), hydrocortisone (Cortef), methylprednisolone (Medrol), and prednisone (Deltasone, Orasone)
• dapsone (Dapsone)
• didanosine (Videx, Videx EC) (take at least 2 hours before or after doses of this medicine)
• digoxin (Digitek, Lanoxicaps, Lanoxin)
• disulfiram (Antabuse)
• dronabinol (Marinol)
• heartburn medicines such as cimetidine (Tagamet), famotidine (Pepcid, Pepcid AC), nizatidine (Axid), and ranitidine (Zantac)
• immunosuppressants such as cyclosporine (Sandimmune, Neoral, Gengraf), tacrolimus (Prograf), and sirolimus (Rapamune)
• inhaled corticosteroid such as fluticasone (Flovent, Flonase, Cutivate)
• isoniazid
• medicines to treat cancer such as paclitaxel (Taxol), docetaxel (Taxotere), and irinotecan (Camptosar)
• mirtazapine (Remeron)
• modafinil (Provigil)
• naproxen (Naprosyn, Anaprox)
• medicines to treat erectile dysfunction such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra)
• other medicines to treat HIV such as abacavir (Ziagen), amprenavir (Agenerase), fosamprenavir (Lexiva), efavirenz (Sustiva), delavirdine (Rescriptor), indinavir (Crixivan), nelfinavir mesylate (Viracept), ritonavir (Norvir), saquinavir (Invirase, Fortovase), tenofovir (Viread), lopinavir/ritonavir (Kaletra), nevirapine (Viramune), zidovudine (AZT), and atazanavir (Reyataz)
• methadone (Dolophine, Methadose)
• methamphetamine (Desoxyn)
• metronidazole (Flagyl)
• natural remedies such as garlic, melatonin, red yeast rice, or St. John's Wort
• proton pump inhibitors such as omeprazole (Prilosec), esomeprazole (Nexium), pantoprazole (Protonix), rabeprazole (AcipHex), and lansoprazole (Prevacid)
• quinine sulfate
• rifabutin (Mycobutin)
• rifampin (Rifadin, Rimactane)
• SSRI antidepressants such as fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), nefazodone, paroxetine (Paxil), venlafaxine (Effexor, Effexor XR), and sertraline (Zoloft)
• tamoxifen (Nolvadex)
• testosterone
• theophylline (Theo-lair)
• tricyclic antidepressants such as amitriptyline (Elavil), nortriptyline (Aventyl, Pamelor), imipramine (Tofranil), doxepin (Sinequan), desipramine (Norpramin), trimipramine (Surmontil), protriptyline (Vivactil), and maprotiline
• warfarin (Coumadin)
• zafirlukast (Accolate)

Keep a list of all your medicines (prescription, nonprescription, supplements, natural remedies, and vitamins) with you. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.