Ondansetron, Oral

What are other names for this medicine?

Type of medicine: 5-HT3 receptor antagonist; antiemetic (antinausea)

Generic and brand names: ondansetron, oral; Zofran ODT

What is this medicine used for?

This medicine is given to prevent nausea and vomiting caused by chemotherapy.

It is also given to prevent or treat nausea and vomiting after surgery.

It is taken by mouth in the form of a liquid, tablet, or disintegrating tablet.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• an allergic reaction to any medicine
• liver disease.
• phenylketonuria (PKU) The orally disintegrating tablet contains phenylalanine.

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

Take this medicine exactly as your healthcare provider prescribes. Ask your healthcare provider or pharmacist about anything you do not understand.

If you are taking the orally disintegrating tablet do not remove from blister pack until needed. Peel the backing off the blister pack. Do not push tablet through the packaging. With dry hands, place tablet on tongue and allow to dissolve in your mouth before swallowing.

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What should I watch out for?

This medicine may make you dizzy or drowsy. Do not drive or operate machinery unless you are fully alert.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Pounding or irregular heartbeat; yellowish skin or eyes, trouble urinating.

Other: Headache, dizziness, drowsiness, shivering, sick feeling, tiredness, diarrhea, constipation, redness at the spot where the shots or infusions were given, anxiety, fever.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• antibiotics such as rifabutin (Mycobutin) and rifampin (Rifadin, Rimactane)
• anticonvulsants such as carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), and primidone (Mysoline)
• apomorphine (Apokyn)

Keep a list of all your medicines (prescription, nonprescription, supplements, natural remedies, and vitamins) with you. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store the tablets at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.