Letrozole, Oral

What are other names for this medicine?

Type of medicine: antineoplastic (anticancer); aromatase inhibitor; hormone antagonist

Generic and brand names: letrozole, oral; Femara

What is this medicine used for?

This medicine is taken by mouth to treat breast cancer in women after menopause (no longer have monthly periods). This treatment is used when the cancer has continued after antiestrogen treatment.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• an allergic reaction to any medicine
• liver disease
• osteoporosis.

Females of childbearing age: Do not take this medicine during pregnancy because it may harm the baby. Avoid becoming pregnant while taking this medicine. If you do become pregnant during treatment with this medicine, notify your healthcare provider right away. Also, tell your healthcare provider if you are breast-feeding.

How do I take it?

Take this medicine once a day with or without food. Taking it with meals may lessen the chance the drug will upset your stomach. Swallow the tablets whole with water. Do not crush or chew the tablets.

Take this medicine exactly as your healthcare provider prescribes. Taking your medicine at the same time each day helps you remember to take it.

Do not stop taking this medicine until your healthcare provider tells you to.

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What should I watch out for?

This medicine may make you dizzy or drowsy. Do not drive or operate machinery unless you are fully alert.

You may need to have lab tests and bone density tests while taking this medicine. Keep all appointments for these tests.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Serious (report these to your healthcare provider right away): Severe muscle and joint pain; chest pain or pressure; swelling of the hands or feet; irregular heartbeat; numbness or loss of strength in any part of your body; trouble speaking; trouble breathing; sudden vision changes.

Other: Nausea, tiredness, headache, constipation, hot flashes, vomiting, diarrhea, loss of appetite, vaginal bleeding, breast tenderness, dizziness, trouble sleeping.

What products might interact with this medicine?

No significant drug interactions have been reported.

Keep a list of all your medicines (prescription, nonprescription, supplements, natural remedies, and vitamins) with you. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.