Isometheptene/Dichloralphenazone/Acetaminophen, Oral

What are other names for this medicine?

Type of medicine: analgesic (painkiller)

Generic and brand names: isometheptene, dichloralphenazone, and acetaminophen, oral; Duradrin; Midrin; Migratine

What is this medicine used for?

This medicine is a combination product used to relieve pain of migraine and tension headaches that are in progress.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• an allergic reaction to any medicine
• circulation problems
• glaucoma
• severe kidney disease
• high blood pressure
• heart disease
• liver disease
• problems with alcohol abuse.

Tell your healthcare provider if you are taking an MAO inhibitor antidepressant such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate). Do not take this medicine and an MAO inhibitor within 14 days of each other.

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Take this medicine exactly as your healthcare provider prescribes. Do not take more than prescribed. If the amount of medicine you are prescribed does not relieve your headache, contact your healthcare provider.

You may take this medicine with or without food. Taking it with meals may lessen the chance the drug will upset your stomach.

If you are taking this medicine on a regular schedule and you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What should I watch out for?

Important notice: Taking an overdose of this medicine can cause very serious problems. If you think you have taken an overdose, get medical care right away.

Check the labels of all nonprescription and prescription medicines you take. Taking other medicines that contain acetaminophen while you take this medicine may lead to an overdose. Ask your healthcare provider or pharmacist if you have any questions.

This medicine may make you dizzy. Do not drive or operate machinery unless you are fully alert.

This medicine increases the effects of alcohol and other drugs that slow down the nervous system. Alcohol may increase the chance of liver damage from this medicine. Do not drink alcohol while taking this medicine. Talk with your healthcare provider about this.

Contact your healthcare provider if your condition does not improve in a few days or if it gets worse.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

This medicine is a controlled substance. It is illegal for you to give it to anyone else.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you are unable to reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Extreme tiredness or weakness; yellowing of the skin or eyes.

Other: Dizziness, drowsiness, rash, nausea.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• antianxiety medicines such as alprazolam (Xanax), chlordiazepoxide (Librium), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), triazolam (Halcion), temazepam (Restoril), flurazepam (Dalmane), and oxazepam (Serax)
• anticonvulsants such as carbamazepine (Tegretol). primidone (Mysoline), gabapentin (Neurontin), felbamate (Felbatol), lamotrigine (Lamictal), levetiracetam (Keppra), topiramate (Topamax), valproic acid (Depacon, Depakene, Depakote), oxcarbazepine (Trileptal), tiagabine (Gabitril) and phenytoin (Dilantin)
• antihistamines such as diphenhydramine (Benadryl), hydroxyzine (Atarax, Vistaril), and chlorpheniramine (Chlor-Trimeton)
• antinausea medicines such as prochlorperazine (Compazine) and promethazine (Phenergan)
• barbiturates such as phenobarbital, butabarbital (Butisol), secobarbital (Seconal), and pentobarbital (Nembutal)
• cholestyramine (Questran)
• diflunisal (Dolobid)
• herbs with sedative effects such as kava, St. John's wort, gotu kola, and valerian
• isoniazid (Laniazid)
• MAO inhibitor antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate) (Do not take this medicine and an MAO inhibitor within 14 days of each other.)
• muscle relaxants such as cyclobenzaprine (Flexeril), carisoprodol (Soma), tizanidine (Zanaflex), methocarbamol (Robaxin), and baclofen (Lioresal)
• other medicines that may contain acetaminophen, such as nonprescription pain, fever, cold, and allergy medicines
• other narcotic painkillers such as codeine, hydrocodone (Vicodin, Lortab), oxycodone (Percocet, Tylox, OxyContin), morphine (MS Contin), propoxyphene (Darvocet N-100), pentazocine (Talwin), meperidine (Demerol), fentanyl (Duragesic patches), methadone (Dolophine), and hydromorphone (Dilaudid)
• rifampin (Rifadin, Rimactane)
• sleeping pills such as zolpidem (Ambien), zaleplon (Sonata), and chloral hydrate
• SSRI antidepressants such as sertraline (Zoloft), fluoxetine (Prozac), citalopram (Celexa), escitalopram (Lexapro), paroxetine (Paxil), venlafaxine (Effexor), and fluvoxamine (Luvox)
• tricyclic antidepressants such as amitriptyline, nortriptyline (Aventyl, Pamelor), imipramine (Tofranil), trazodone (Desyrel), desipramine (Norpramin), and doxepin (Sinequan)
• warfarin (Coumadin).

Do not drink alcohol while taking this medicine.

Keep a list of all your medicines (prescription, nonprescription, supplements, natural remedies, and vitamins) with you. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.