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Complications of Deep Vein Thrombosis

With deep vein thrombosis, a blood clot may grow large enough to block blood flow within a vein. When this happens, complications may develop that pose immediate health threats, and can even be fatal if not treated. Seek treatment right away if you have any of the symptoms described below.

Outline of human torso showing heart, lungs, and major veins. Blood clot is in leg vein with arrow showing it traveling up vein to lung causing pulmonary embolism.

Pulmonary Embolism

A pulmonary embolism (PE) occurs when an embolus (a piece of blood clot) in the bloodstream travels through the heart and into the lungs. If the embolus becomes lodged in a blood vessel in the lungs, blood flow can be blocked. Symptoms can quickly develop and cause life-threatening heart and lung problems.

Call the healthcare provider right away if you have any of the following:

  • Chest pain (call 911)

  • Trouble breathing (call 911)

  • Coughing up blood (call 911)

  • Fainting (call 911)

  • Skin turns blue (call 911)

  • Dizziness

  • Rapid, pounding, or unusual heartbeat

  • Sweating more than usual

  • Unusual swelling or pain in your leg

Post-Thrombotic Syndrome

If a blood clot remains in a vein for some time, it can cause severe damage. Blood can pool in a leg vein. This can cause ongoing pain, swelling, and skin damage, resulting in a condition called post-thrombotic syndrome. If symptoms are not controlled, you can even develop open wounds on the leg called venous skin ulcers.


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