Alexander Khoruts, MD

Philosophy of Care:

A physician is first and foremost a patient advocate. The patient must feel secure that he or she is getting the best care possible, will not have to face illness alone, and will be heard and understood.

Medical Title:

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Clinical Interests:

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Board Certifications:

2001 – 2003 Department of Medicine Young Investigator Award, University of Minnesota

Reinhardt R.L., Khoruts A., Merica, R., Zell, T., and M.K. Jenkins. 2001. Visualizing the generation of memory CD4 T cells in the whole body. Nature 410:101-105.

Thorstenson, K.M., and A. Khoruts. 2001. Generation of anergic and potentially immunoregulatory CD25+CD4+ T cells in vivo following induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 188-195.

Moses, C.T., Thorstenson, K.M., Jameson, S.C., and A. Khoruts. 2003. Competition for self ligands restrains homeostatic proliferation of naïve CD4 T cells. Proc. Natl. Acad. Sci. USA. 100:1185-1190.

Hagen, K., Moses, C.T., Drasler, E.F., Podetz-Pedersen, K., Jameson, S.C., and A. Khoruts. 2004. A role for CD28 in lymphopenia-induced proliferation of CD4 T cells. J. Immunol. 173:3909-3915.

Hataye, J., Moon, J.J., Khoruts, A., Reilly, C.S., and M.K. Jenkins. 2006. Naïve and memory CD4+ T cell survival controlled by clonal abundance. Science 312:114-116.

Fischer, U.B., Jacovetty, E.L., Medeiros, R.B., Goudy, B.D., Zell, T., Swanson, J.B., Shimizu, Y., Miller, M.J., Khoruts, A.*, and E. Ingulli*. 2007. MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo. Proc. Natl. Acad. Sci. USA 104:7181-7186. *Authors equal contributors.

Kang, J., Huddleston, S.J., Fraser, J.M., and A. Khoruts. 2008. De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR. J. Leukoc. Biol. 83:1230-1239.

Winstead, C.J., Fraser, J.M., and A. Khoruts. 2008. Regulatory CD4+CD25+Foxp3+ T cells selectively inhibit the spontaneous form of lymphopenia-induced proliferation of naive T cells. J. Immunol. 180:7305-7317.

Khoruts, A., Dicksved, J., Jansson, J.K., and Sadowsky, M.J. 2010. Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea. J. Clin. Gastroenterol. 44:354-360.

Winstead, C.J., Reilley, C.S., Moon, J.J., Jenkins, M.K., Hamilton, S.E., Jameson, S.C., Way, S.S., and Khoruts, A. 2010. CD4+CD25+Foxp3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia. J. Immunol., 184:4749-4760.

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