Brenda Weigel, MD, MSc

Brenda Weigel, MD, MSc
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Journey Clinic: Center for Children with Cancer and Blood Diseases
East Building, Ninth Floor
2450 Riverside Ave.
Minneapolis MN 55454

Medical Title:

Academic Appointments:


Clinical Interests:

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Board Certifications:

Mpls. St. Paul Magazine "Top Doctor" - (2012, 2014)

Best Doctors in America®, 2009-2010

Alexander Charles Jundt Research Award, 2005

Lehman/Children's Cancer Research Fund, Endowed Chair in Pediatric Cancer, 2004

University Pediatrics Foundation Scholar Award, University of Minnesota, 2003

Translational Research Award, Children's Oncology Group, 2002

Young Investigator Award, Children's Oncology Group, 2001

Young Investigator Award, Children's Oncology Group (formerly known as Children's Cancer Group), 2000 

Young Investigator Award, American Society of Clinical Oncology, 1999

Chief Fellow, Pediatric Hematology/Oncology,University of Minnesota, 1998-2000

PAIRO Residency Teaching Award, 1995-1996

Chief Resident, Pediatrics, University of Western Ontario, 1995-1996

Farquharson Fund - MRC Research Scholarship, 1991-1992

Research Training Fellowship, The Research Institute of The Hospital for Sick Children, 1989-1990

Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood 117(17):4501-10, 2011. PMID: 21385853
Geller M, Cooley S, Argenta P, Downs L, Carson L, Judson P, Ghebre R, Weigel B, Panoskaltsis-Mortari A, Curtsinger J, Miller J. Toll-like receptor-7 (TLR-7) agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancers. Cancer Immunol Immunother 59(12):1877-84, 2010. PMID: 20820775
Zhou Q, Munger ME, Highfill WE, Tolar J, Weigel BJ, Riddle M, Sharpe AH, Vallera DA, Azuma M, Levine BL, June CH, Murphy WJ, Munn DH, Blazar, BR. Program death-1 (PD-1) signaling and regulatory T cells (Tregs) collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes (CTLs) in advanced acute myeloid leukemia (AML). Blood 116(14):2484-93, 2010. PMID: 20570856
Ahn YO, Weigel B, Verneris MR. Killing the killer: natural killer cells to treat Ewing’s sarcoma. Clin Cancer Res 16(15):3819-21, 2010. PMID: 20554750
Zhou Q, Bucher C, Munger ME, Highfill SL, Tolar J, Munn DH, Levine B, Riddle M, June CH, Vallera DA, Weigel BJ, Blazar BR. Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive immunotherapy in murine acute myeloid leukemia. Blood 114(18):3793-802, 2009. PMID: 19724059
Weigel BJ, Blaney SM, Reid JM, Safgren SL, Bagatell R, Kersey J, Neglia JP, Ivy SP, Ingle AM, Whitesell L, Gilbertson RJ, Krailo M, Ames M, Adamson PC. A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children’s Oncology Group study. Clin Cancer Res 13(6):1789-93, 2007. PMID: 17363534
Yao Q, Weigel B, Kersey J. Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51. Clin Cancer Res 13(5):1591-600, 2007. PMID: 17332306
Weigel BJ, Panoskaltsis-Mortari A, Diers M, Garcia M, Lees C, Krieg AM, Chen W, Blazar BR. Dendritic cells pulsed or fused with AML cellular antigen provide comparable in vivo antitumor protective responses. Exp Hematol 34(10):1403-12, 2006. PMID: 16982333
Fraser CJ, Weigel BJ, Perentesis JP, Dusenbery KE, DeFor TE, Baker KS, Verneris MR. Autologous stem cell transplantation for high-risk Ewing’s sarcoma and other pediatric solid tumors. Bone Marrow Transplant 37(2):175-81, 2006. PMID: 16273111
Smith AR, Repka TL, Weigel BJ. Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents. Pediatr Blood Cancer 45(6):857-60, 2005. PMID: 15849684
Nagarajan R, Clohisy D, Weigel B. New paradigms for therapy for osteosarcoma. Curr Oncol Rep 7(6):410-4, 2005. PMID: 16221377
Sauer MG, Ericson ME, Weigel BJ, Herron MJ, Panoskaltsis-Mortari A, Kren BT, Levine BL, Serody JS, June CH, Taylor PA, Blazar BR. A novel system for simultaneous in vivo tracking and biological assessment of leukemia cells and ex vivo generated leukemia-reactive cytotoxic T cells. Cancer Res 64(11):3914-21, 2004. PMID: 15173002
Weigel BJ, Rodeberg DA, Krieg AM, Blazar BR. CpG oligodeoxynucleotides potentiate the antitumor effects of chemotherapy or tumor resection in an orthotopic murine model of rhabdomyosarcoma. Clin Cancer Res 9(8):3105-14, 2003. PMID: 12912962
Weigel BJ, Nath N, Taylor PA, Panoskaltsis-Mortari A, Chen W, Krieg AM, Brasel K, Blazar BR. Comparative analysis of murine marrow-derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of antileukemia responses. Blood 100(12):4169-76, 2002. PMID: 12393694
Weigel BJ, Breitfeld PP, Hawkins D, Crist WM, Baker KS. Role of high-dose chemotherapy with hematopoietic stem cell rescue in the treatment of metastatic or recurrent rhabdomyosarcoma. J Pediatr Hematol Oncol 23(5):272-6, 2001. PMID: 11464981
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