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Discharge Instructions: Using Injection Pens

Your doctor has prescribed a medicine that you can give yourself using an injection pen. One medicine that is commonly given with an injection pen is insulin. Injection pens are popular because they are easy to use. Also, many people like how pens look better than syringes. Pens can be disposable or nondisposable.

Disposable pens come already filled with a set amount of medicine. Once you inject the medicine, you throw the pen away. With nondisposable pens, you replace the medicine cartridge when it is empty.

Both types of pens need a pen needle. This is screwed onto the tip of the pen before injection. Pen needles come in various lengths and thicknesses.

Gather your supplies

  • Alcohol swabs

  • Injector pen

  • Cartridge if pen is the nondisposable type

  • Puncture-proof container for used needles and disposable pens. The FDA recommends using FDA-approved containers. These are sturdy plastic containers you can get from a drugstore, medical supply company, health care provider, or online.

Prepare the pen

Each pen will come with its own special instructions. Read the directions that came with your pen. Discuss the instructions with your diabetes care team or diabetes educator before injecting insulin. In general here is what to do:

  • Wash your hands.

  • Remove the pen cap.

  • Check the medicine. Make sure it is the type your doctor prescribed. Check that it hasn't expired, and that it's not discolored, frosted, or lumpy. If the medicine doesn't look right to you, don’t use it. Get a new cartridge or a new disposable pen. Never share injection pens or medicine cartridges.

  • Some medicines need to be mixed. You can do this by rolling the pen between your palms about 20 times. You can also tip the pen back and forth.

  • Attach a needle to your pen. Read the directions that came with your pen. They will give you the steps for attaching a needle. If you’re using a nondisposable pen, don’t leave the needle attached to the pen between shots.

Prime the pen and set the dose

Prime your pen and make sure that it's working by doing a trial "air shot" before actually injecting your medicine. Then set the dose.

  • Dial the pen to deliver 2 or 3 units of medicine.

  • Hold the pen like a pencil, with the needle pointing up.

  • Tap the barrel of the pen. This will make sure that any air bubbles in the cartridge float to the top of the cartridge.

  • Push down firmly on the pen's injector button. This will "shoot" medicine into the air. You should see a couple of drops of medicine come out of the needle. If nothing comes out, try doing another air shot. If medicine still doesn't come out after a second try, your pen may be low on medicine or the needle may not be connected properly. Look at the troubleshooting tips in the directions that came with your pen.

  • Set your dose. Dial the pen to deliver the amount of medicine you need to take. As you turn the dial, you should hear a clicking sound. Your pen is now ready to use.

Inject your medicine

  • Choose an injection site. The abdomen, upper arms, thighs, and buttocks are the most common sites to use. Stay away from sites that are close to a mole or scar, or that are within 2 inches of your belly button.

  • Make sure the site is clean. Clean it with an alcohol swab. Let it dry.

  • Pinch up a fold of skin around the site you've picked. Hold it firmly with one hand.

  • In the other hand, hold the injection pen like a pencil.

  • Put the needle straight into the pinched-up skin (at a 90° angle). Thin adults or children may need to inject at a 45° angle.

  • Make sure the needle gets all the way into the fatty tissue below the skin.

  • Push the pen injection button. Unless you take a very small dose, the injection should take a couple of seconds. Depending on the insulin pen you are using, you may have to hold the pen in 5 to 10 seconds after injecting the insulin. Carefully follow the instructions that came with your pen. Or follow the advice your diabetes care team or diabetes educator gives you.

  • Let go of the skin and withdraw the needle from your skin.

After the injection

  • If you are using a nondisposable pen, remove the needle by unscrewing it.

  • Dispose of any used needles or disposable pens in the puncture-proof container.

  • Take the full container back to your health care facility so it can be thrown away properly.

Follow-up care

Make a follow-up appointment as directed by our staff.


When to seek medical care 

Call your doctor right away if you have any of the following:

  • Problems that stop you from giving your injection

  • Bleeding at the injection site for more than 10 minutes

  • Pain at the injection site that does not go away

  • Accidental or improper injection

    • Injecting the medicine in the wrong area

    • Injecting too much medicine

  • Rash at the injection site

  • Fever above 100.0°F (37.78°C)

  • Redness, warmth, swelling, or drainage at the injection site

  • Signs of allergic reaction (trouble breathing, hives, rash)


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